A gain-of-function mutation in which of the following would promote malignancy in cells whose proliferation is inhibited by TGFβ?
A)co-Smad
B)I-Smad
C)R-Smad
D)all of the above
E)none of the above

Question

Quizplus · Accepted Answer

A gain-of-function mutation in I-Smad (inhibitory Smad) would promote malignancy by inhibiting the TGFβ signaling pathway, which normally suppresses cell proliferation.

A Gain-Of-Function Mutation in Which of the Following Would Promote