Small G proteins,including Rho,Rac,and Cdc42,contribute to the coordinated movement and overall polarity of a migrating cell.Assuming that the cell is migrating in a left-to-right fashion,which of the following is correct?
A)active Cdc42 at the leading edge of the cell and active Rho at the back of the cell
B)active Rac at the back of the cell and active Cdc42 at the front of the cell
C)active Cdc42 at the back of the cell and active Rac at the leading edge of the cell
D)active Rac at the leading edge of the cell and active Rho at the back of the cell

Question

Quizplus · Accepted Answer

Active Cdc42 at the leading edge of the cell promotes actin polymerization and membrane protrusion, which is necessary for cell migration. Active Rho at the back of the cell promotes actomyosin contractility, which is necessary for cell retraction.

Small G Proteins,including Rho,Rac,and Cdc42,contribute to the Coordinated Movement and Overall