Separase initiates sister chromatid segregation at anaphase by cleaving:
A)APC.
B)Cdc20.
C)cyclin B.
D)Scc1.

Question

Quizplus · Accepted Answer

Separase cleaves the cohesin subunit Scc1, which holds the sister chromatids together, to initiate sister chromatid separation at anaphase. APC and Cdc20 are involved in regulating the initiation of anaphase, but not in the actual cleavage of cohesin. Cyclin B is involved in regulating entry into mitosis, but not in sister chromatid segregation at anaphase.

Separase Initiates Sister Chromatid Segregation at Anaphase by Cleaving