Which of the following statements best describes the difference between low-affinity integrins and high-affinity integrins?
A)Many integrins can exist in two conformations: a low-affinity (bent)conformation and a high-affinity (straight)conformation.
B)Dissociation of the αβ heterodimer converts many integrins from the low-affinity to the high-affinity state.
C)Association of the αβ heterodimer converts many integrins from the low-affinity to the high-affinity state.
D)Proteolytic cleavage of the C-terminal tails of the two subunits converts many integrins from the low-affinity to the high-affinity state.

Question

Quizplus · Accepted Answer

Low-affinity integrins have a bent conformation, while high-affinity integrins have a straight conformation. Many integrins can exist in both conformations by undergoing conformational changes. The dissociation or association of the αβ heterodimer or proteolytic cleavage of the C-terminal tails of the two subunits does not necessarily affect the affinity state of integrins.

Which of the Following Statements Best Describes the Difference Between