Fully differentiated mouse fibroblasts can be reprogrammed or induced to form pluripotent stem cells when transfected with retroviral vectors that express:

Question

Quizplus · Accepted Answer

All three genes, KLF4, c-MYC, and SOX2 are necessary for inducing pluripotency in mouse fibroblasts. These genes, along with OCT4, are known as the Yamanaka factors and play a critical role in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). Therefore, choice D (all of the above) is the correct answer.

Fully Differentiated Mouse Fibroblasts Can Be Reprogrammed or Induced to Form