In cells that have been signaled to die via TNF-a receptor signaling but lack caspase-8 activity:

Question

Quizplus · Accepted Answer

When cells lack caspase-8 activity, apoptosis cannot occur via the traditional caspase-mediated pathway. However, TNF-a receptor signaling can activate an alternative pathway known as necroptosis. This pathway involves the activation of RIP proteins and ultimately leads to the activation of MLKL, which causes cell death via necrosis-like mechanisms. Therefore, in cells lacking caspase-8 activity, necroptosis would occur downstream of RIP protein activation of MLKL.

In Cells That Have Been Signaled to Die Via TNF-A