Which of the following would occur from B-cell class switching?

Question

Quizplus · Accepted Answer

Class switching is the process by which a B-cell changes the class of its antibody production from one isotype (e.g. IgM) to another (e.g. IgG). This occurs through a recombination event in the constant (C) region of the heavy chain gene. The antigen specificity of the antibody remains the same, but the effector functions of the antibody may change (e.g. IgG can activate complement and bind to Fc receptors on certain immune cells). Therefore, the production of IgG γ2 with the same antigen specificity is the best choice. Option A is incorrect because rearrangement of the light chain does not occur during class switching. Option B is incorrect because the VDJ recombination is already established in the initial B-cell differentiation and does not change during class switching. Option C is incorrect because IgA is primarily secreted across mucosal surfaces, not in the bloodstream.

Which of the Following Would Occur from B-Cell Class Switching