In the thymus,T cells can be deleted only if:

Question

Quizplus · Accepted Answer

T cells can only be deleted in the thymus if the appropriate self-antigen is represented adequately in the thymus as MHC-peptide complexes AND the T cell cannot engage self MHC proteins. This is the process of negative selection and is necessary to ensure that T cells do not attack self-tissues. Option A is partially correct but does not take into account the requirement for the T cell to not engage self MHC. Option B is incorrect because the absence of self-antigen does not contribute to negative selection. Option C is incorrect because the engagement of self MHC by T cells is necessary for positive selection, not negative selection.

In the Thymus,T Cells Can Be Deleted Only If