A patient with B cell leukemia donates some cancer cells for analysis.The cells do not contain the usual chromosomal translocations associated with leukemia.Instead,a sporadic mutation seems to have arisen in a certain gene,followed by loss of heterozygosity in the second copy.This gene product is most likely:

Question

Quizplus · Accepted Answer

The loss of heterozygosity in the second copy of a gene suggests that it is a tumor suppressor gene. The only option that is a tumor suppressor gene is Rb (retinoblastoma gene). Ras is an oncogene, VEGF is a growth factor gene, and telomerase is an enzyme that maintains telomeres, which are not associated with this type of leukemia.

A Patient with B Cell Leukemia Donates Some Cancer Cells