How Does Tissue Damage Occur in Acute Rejection After an Organ

How does tissue damage occur in acute rejection after an organ transplant?

A) Helper T cells (Th1) release cytokines that activate infiltrating macrophages and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue.
B) Circulating immune complexes are deposited in the endothelial cells of transplanted tissue where the complement cascade lyses tissue.
C) Antigens on the cell surface of transplanted tissue are recognized by receptors on natural killer (NK) cells,which release lysosomal enzymes that destroy tissue.
D) Antibodies coat the surface of transplanted tissue to which mast cells bind and liberate preformed chemical mediators that destroy tissue.