Brain death has occurred when there is no discernable evidence of cerebral hemisphere function or function of the brain stem's vital centers for 1 to 6 hours.

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Brain death is declared when there is no activity in the cerebral hemispheres and the brain stem for a period of 1 to 6 hours, depending on the standards of the hospital or medical facility. This is considered irreversible and is a legal and medical determination of death.

Brain Death Has Occurred When There Is No Discernable Evidence