Clinical manifestations of mild to moderate splenomegaly and hepatomegaly,bronze skin,and cardiac dysrhythmias are indicative of which anemia?
A) Iron deficiency
B) Pernicious
C) Sideroblastic
D) Aplastic

Question

Quizplus · Accepted Answer

Clinical manifestations of mild to moderate splenomegaly and hepatomegaly, bronze skin, and cardiac dysrhythmias are indicative of sideroblastic anemia. This is because the abnormal production of heme in the bone marrow leads to the accumulation of iron in the mitochondria of erythroblasts, resulting in ineffective erythropoiesis and ultimately anemia. Iron deficiency anemia usually presents with fatigue, weakness, pallor, and possibly spoon-shaped nails. Pernicious anemia is characterized by a deficient production of intrinsic factor, which impairs absorption of vitamin B12 and leads to the production of enlarged, immature erythrocytes. Aplastic anemia involves the failure of the bone marrow to produce blood cells, leading to pancytopenia, fatigue, and infections.

Clinical Manifestations of Mild to Moderate Splenomegaly and Hepatomegaly,bronze Skin,and