Erythrocyte life span less than 120 days,ineffective bone marrow response to erythropoietin,and altered iron metabolism describe the pathophysiology of which anemia?
A) Aplastic anemia
B) Sideroblastic anemia
C) Anemia of chronic disease
D) Iron deficiency anemia

Question

Quizplus · Accepted Answer

The pathophysiology described is characteristic of anemia of chronic disease, which is often seen in chronic inflammatory conditions, infections, and malignancies. The shortened erythrocyte lifespan is due to increased destruction by macrophages, the bone marrow response to erythropoietin is reduced, and there is altered iron metabolism with sequestration of iron in macrophages. Aplastic anemia is characterized by hypocellular bone marrow, Sideroblastic anemia is characterized by abnormal iron metabolism leading to iron accumulation in erythropoietic cells, and iron deficiency anemia is characterized by depleted iron stores and decreased hemoglobin synthesis.

Erythrocyte Life Span Less Than 120 Days,ineffective Bone Marrow Response