The greatest single risk factor for reactivation of tuberculosis is infection with human immunodeficiency virus (HIV).

Question

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HIV weakens the immune system, making it harder for the body to fight off TB bacteria. This increases the risk of latent TB infection progressing to active TB disease. In people with HIV, active TB disease can develop quickly and be more severe, often involving multiple organs.

The Greatest Single Risk Factor for Reactivation of Tuberculosis Is