Which statement is false about the skeletal alterations caused by chronic renal failure? A) When the glomerular filtration rate (GFR)declines to 25% of normal,parathyroid hormone (PTH)is no longer effective in maintaining serum phosphate levels. B) When the glomerular filtration rate (GFR)declines to 25% of normal,the parathyroid gland is no longer able to secrete sufficient parathyroid hormone (PTH). C) When the glomerular filtration rate (GFR)declines to 25% of normal,there is impaired synthesis of 1,25-vitamin D₃,which reduces intestinal absorption of calcium. D) When the glomerular filtration rate (GFR)declines to 25% of normal,there is impaired synthesis of 1,25-vitamin D₃,which impairs the effectiveness of calcium and phosphate resorption from bone by parathyroid hormone (PTH).

Question

Quizplus · Accepted Answer

When the GFR declines to 25% of normal, the parathyroid gland actually secretes more parathyroid hormone (PTH) in an attempt to maintain serum calcium levels. However, this increased secretion of PTH can lead to bone resorption and skeletal alterations in chronic renal failure patients.

Which Statement Is False About the Skeletal Alterations Caused by Chronic