What is the pathophysiologic process in hemolytic-uremic syndrome?
A) An autoimmune disorder in which immunoglobulin A (IgA)coats erythrocytes that are destroyed by the spleen and remnants are excreted through the kidneys.
B) Verotoxin from E.coli is absorbed from the intestines and damages erythrocytes and endothelial cells.
C)Endotoxins from E.coli block the erythropoietin produced by the kidneys,which reduces the number of erythrocytes produced by the bone marrow.
D)Failure of the nephron to filter urea increases the blood urea nitrogen,which binds to erythrocytes that are subsequently destroyed by the spleen.

Question

Quizplus · Accepted Answer

Hemolytic-uremic syndrome is caused by verotoxin (also known as Shiga toxin) produced by certain strains of E.coli bacteria. The toxin damages erythrocytes and endothelial cells, leading to the formation of small blood clots in the small blood vessels of the kidneys. This can result in hemolysis (destruction of red blood cells), thrombocytopenia (low platelet count) and acute kidney injury.

What Is the Pathophysiologic Process in Hemolytic-Uremic Syndrome