What causes the bone to die in osteomyelitis?
A) Formation of immune complexes at the site of infection
B) Localized ischemia
C) Tumor necrosis factor alpha (TNF-)and interleukin 1 (IL-1)
D) Impaired nerve innervation at the site of infection

Question

Quizplus · Accepted Answer

Localized ischemia occurs in osteomyelitis as a result of the infection causing inflammation and blocking blood flow to the affected area, leading to bone necrosis.

Answer: C
 TNF-alpha and IL-1 are pro-inflammatory cytokines that are released in response to infection and can contribute to bone destruction in osteomyelitis.

Therefore, the best choices are B and C.

What Causes the Bone to Die in Osteomyelitis