Monoclonal antibodies can produce spurious results in nephelometry.

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The disadvantages of nephelometry include high initial equipment cost and interfering substances such as microbial contamination,which may cause protein denaturation and erroneous test results.Intrinsic specimen turbidity or lipemia may exceed the preset limits.In these cases,a clearing agent may be needed before an accurate assay can be performed.In addition,low-molecular-weight immunoglobulins and monoclonal immunoglobulins also may produce spurious results in nephelometry.

Monoclonal Antibodies Can Produce Spurious Results in Nephelometry