The most frequent cause(s)of mortality in hospitalized patients with SLE and progressive renal involvement or CNS disease is (are):

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Survival is estimated to be greater than 90% at 10 years after diagnosis.The highest mortality rate is in patients with progressive renal involvement or CNS disease.The two most frequent causes of death are renal failure and infectious complications.Infections are the leading cause of death in hospitalized patients.Infections can be caused by bacterial,viral,fungal,or parasitic pathogens.Immunosuppression produced by treatment (e.g. ,steroids)can interfere with host defense against opportunistic infections (e.g. ,Mycobacterium tuberculosis,Histoplasma capsulatum,Listeria monocytogenes).

The Most Frequent Cause(s)of Mortality in Hospitalized Patients with SLE