A major cellular immunologic feature of SLE is:

Question

Quizplus · Accepted Answer

Systemic lupus erythematosus is a disease that results from defects in the regulatory mechanism of the immune system.Studies of the immunopathogenesis of lupus nephritis have demonstrated a variety of aberrations in T cell and B cell function.It is uncertain whether the disease represents a primary dysfunction of T cells or B cells,but alterations in function do result.Lymphocyte subset abnormalities are a major immunologic feature of SLE.Among the T cell subsets,a lack of or reduced generalized suppressor T cell function and hyperproduction of helper T cells occur.The formation of lymphocytotoxic antibodies with a predominant specificity for T lymphocytes by patients with SLE at least partially explains the interference with certain functional activities of T lymphocytes associated with SLE.Lymphocytotoxic antibodies are capable of destroying T lymphocytes in the presence of complement and coating peripheral blood T cells.

A Major Cellular Immunologic Feature of SLE Is