In RA,stimulated macrophages and fibroblasts release cytokines.One that is particularly important is:

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Stimulated macrophages and fibroblasts release cytokines,including tumor necrosis factor-a (TNF-a),a central component in the cascade of cytokines.This results in the production of additional inflammatory mediators and further recruitment of immune and inflammatory cells into a joint.Anti-TNF-a treatment strategies (e.g. ,monoclonal)prevent interaction with receptors on cell surfaces.

In RA,stimulated Macrophages and Fibroblasts Release Cytokines