A major,genetically determined change in the antigenic character of a pathogen is called antigenic drift.

Name: A major,genetically determined change in the antigenic character of a pathogen is called antigenic drift.
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Antigenic drift refers to minor changes or mutations in the genes of a pathogen that can lead to changes in its surface proteins (antigens). Major, genetically determined changes in the antigenic character of a pathogen are referred to as antigenic shift.

A Major,genetically Determined Change in the Antigenic Character of a Pathogen