Microbiome sequencing requires the construction of a genomic library,while whole-genome shotgun sequencing does not.

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Whole-genome shotgun sequencing involves fragmenting the entire genome into small pieces and sequencing them, without the need for constructing a genomic library. In contrast, microbiome sequencing involves constructing a genomic library from the mixed community of microorganisms present in a sample before sequencing.

Microbiome Sequencing Requires the Construction of a Genomic Library,while Whole-Genome