Enhancer sequences for transcription activation in eukaryotes can exert effects from a great distance of the transcription target by forming loops or changing DNA structural elements.

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Enhancer sequences have been shown to exert their effects from a distance by looping, changing chromatin structure or interacting with other proteins, and can regulate transcription even if located far away from the target gene.

Enhancer Sequences for Transcription Activation in Eukaryotes Can Exert Effects