In the TCA cycle,two carbons are removed from citric acid in the form of __________,thereby regenerating oxaloacetate to complete the cycle.

Question

Quizplus · Accepted Answer

In the TCA cycle, two carbons are lost as carbon dioxide during the conversion of isocitrate to α-ketoglutarate and then during the conversion of α-ketoglutarate to succinyl-CoA. These carbons are carried away in the form of CO2, and the remaining carbons are transferred to a molecule of CoA, forming acetyl-CoA. The regeneration of oxaloacetate is necessary to complete the cycle, and this occurs when the four-carbon molecule succinyl-CoA is converted to four-carbon molecule oxaloacetate in the presence of the enzyme succinyl-CoA synthetase.

In the TCA Cycle,two Carbons Are Removed from Citric Acid