The Vaginal Microbiome Changes as a Female Matures Because

The vaginal microbiome changes as a female matures because

A) hormonal changes and sexual activity alter the environment of the vagina.
B) estrogen has an antibiotic effect on the vaginal microbiome.
C) most sexually mature women use douching as a means to eliminate the vaginal microbiome.
D) episodic treatments with antibiotics for UTIs and antifungals for vaginitis eliminate many of the normal microbiota.