In systemic lupus erythematosis (called lupus), complexes of antibody and antigen form, and these immune complexes insert themselves into small blood vessels, joints, heart, and kidney, causing damage to the organ tissue.The course of the disease is unpredictable, with periods of illness alternating with remissions.How is lupus, a type III autoimmune disease, similar to the tuberculin reaction, a type IV hypersensitivity reaction?

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Both lupus and the tuberculin reaction involve the release of large amounts of inflammatory chemicals into tissue, causing damage and inflammation. However, lupus is a type III autoimmune disease in which immune complexes form and insert themselves into tissue, while the tuberculin reaction is a type IV hypersensitivity reaction in which T-cells react to an antigen in the skin. Neither lupus nor the tuberculin reaction involves IgE, and the tuberculin reaction is not an immediate hypersensitivity, as it can take up to 72 hours to develop.

In Systemic Lupus Erythematosis (Called Lupus), Complexes of Antibody and Antigen