The first signs of neurodegeneration in Huntington's disease involve loss of
A) neurons involved in the synthesis of nitrous oxide.
B) dopamine-secreting neurons of the nigrostriatal system.
C) neurons involved in glucose metabolism.
D) GABAergic neurons of the putamen.
E) cholinergic neurons in the pons.

Question

Quizplus · Accepted Answer

The first signs of neurodegeneration in Huntington's disease involve the loss of GABAergic neurons in the putamen. This leads to the disruption of the delicate balance between the direct and indirect pathways, which contribute to the control of movement. As a result, the typical motor symptoms of the disease, such as chorea and dystonia, begin to manifest.

The First Signs of Neurodegeneration in Huntington's Disease Involve Loss