The Monoamine Hypothesis of Depression Is NOT Supported by the Observation

The monoamine hypothesis of depression is NOT supported by the observation that

A) monoamine antagonists produce depression.
B) CSF levels of 5-HIAA are low in suicidal patients.
C) monoamine agonists produce depression.
D) families of subjects with low 5-HIAA levels were more likely to include people with depression.
E) reserpine causes depression.