During the pairing of homologs in prophase of meiosis I, the region of a chromosome bearing extra copies of a particular chromosomal region that has nothing with which to recombine with forms a

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During the pairing of homologs in prophase of meiosis I, if a chromosome has an extra copy of a particular chromosomal region (a duplication), it forms a duplication loop when it pairs with its homolog. This is because the duplicated region cannot align with its counterpart on the homolog and instead forms a loop. This loop can cause unequal crossing over during meiosis, which can lead to genetic disorders.

During the Pairing of Homologs in Prophase of Meiosis I