What is the reason that aneuploidy in autosomal chromosomes is generally not tolerated as well as aneuploidy in sex chromosomes in humans?
A)Only one X chromosome is active in any somatic cell
B)Autosomal aneuplody leads to heart defects and death in utero
C)Y chromosome duplication results in only minor changes in testosterone levels
D)Sex chromosome aneuploids may occur as the result of fertilization but the any extra sex chromosomes are removed from the developing embryo during subsequent mitosis.
E)increased susceptibility to infection.

Question

Quizplus · Accepted Answer

In humans, only one X chromosome is active in any somatic cell, with the other X chromosome being inactivated through a process called X inactivation. This means that aneuploidy in sex chromosomes may not have as severe consequences as aneuploidy in autosomal chromosomes, where the presence of an extra or missing chromosome can disrupt normal gene dosage balance and lead to developmental abnormalities or even death.

What Is the Reason That Aneuploidy in Autosomal Chromosomes Is