An XY individual carries mutations in both the SRY and AR genes.Which anatomic sex is this individual expected to be?
A)Female
B)Male

Question

Quizplus · Accepted Answer

The SRY gene, located on the Y chromosome, is responsible for the development of testes and the secretion of testosterone in embryonic males. Mutations in this gene can lead to female genitalia development. The AR gene, located on the X chromosome, codes for the androgen receptor protein which is necessary for cells to respond to androgens such as testosterone. Mutations in this gene can result in androgen insensitivity syndrome (AIS), where the body is unable to respond to androgens, leading to incomplete masculinization of the body. Therefore, an individual with mutations in both the SRY and AR genes would be expected to have female genitalia and would likely present with AIS.

An XY Individual Carries Mutations in Both the SRY and AR