Antibodies Are Made Against a Very Small Portion of an Antigen

Antibodies are made against a very small portion of an antigen called an epitope.An epitope is often just five to six amino acids from a protein on an antigen.Which explains how antibodies could be produced against just a small part of an antigen?

A) T helper cells secrete enzymes that digest the pathogen.
B) B cells produce antibodies that bind directly to a single epitope on the antigen.
C) Cytotoxic T cells poke holes in the antigen.
D) Complement protein pokes holes in the antigen.
E) Macrophages engulf and digest the pathogen.