Xeroderma Pigmentosum (XP)is a rare autosomal recessive disorder.Patients with XP exhibit a cellular hypersensitivity to ultraviolet (UV)radiation,a high incidence of skin cancer and premature aging.Based on these clinical characteristics,what is the underlying cause for this disease?

Question

Quizplus · Accepted Answer

Xeroderma Pigmentosum is caused by defects in DNA repair mechanisms, especially nucleotide excision repair, which results in the inability to repair UV-induced DNA damage. This leads to the accumulation of DNA damage, which causes cell death, mutations, and eventually cancer development in affected individuals.

Xeroderma Pigmentosum (XP)is a Rare Autosomal Recessive Disorder