What would you expect to happen if the anaphase-promoting complex (APC)failed to ubiquitinate securin?
A)The cohesin complex will be destroyed,and the cell will remain in metaphase.
B)The cohesin complex will persist,preventing the cell from entering anaphase.
C)Separase will be marked for degradation by securin,preventing the cell from entering anaphase.
D)Inhibition of separase will be lifted,allowing securin to destroy cohesin and preventing the cell from entering anaphase.

Question

Quizplus · Accepted Answer

If the APC fails to ubiquitinate securin, securin will not be degraded and will still inhibit separase. This will prevent the separation of sister chromatids as separase will not be able to cleave the cohesin complex. Therefore, the cohesin complex will persist, preventing the cell from entering anaphase.

What Would You Expect to Happen If the Anaphase-Promoting Complex