The disease that involves the muscles and often manifests itself first with spasms of the jaw muscles is

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Tetanus, also known as lockjaw, is a disease that affects the muscles and is caused by a bacterial toxin. It often starts with spasms of the jaw muscles, making it difficult to open the mouth. Gastritis is a disease that affects the stomach lining, while polio and rabies are viral diseases that do not present with jaw muscle spasms as a defining symptom.

The Disease That Involves the Muscles and Often Manifests Itself