The phrase "one gene-one enzyme" is associated with the work of

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The phrase "one gene-one enzyme" was coined by George Beadle and Edward Tatum in their work on the bread mold Neurospora crassa, for which they received the Nobel Prize in Physiology or Medicine in 1958. They showed that a single gene controlled the synthesis of a single enzyme, which in turn catalyzed one specific biochemical reaction. This discovery opened up a new field of research called biochemical genetics, which provided important insights into the relationship between genes and proteins.

The Phrase "One Gene-One Enzyme" Is Associated with the Work