Linus Pauling and his colleagues discovered that a mutant gene involved in the synthesis of hemoglobin causes sickle cell anemia.

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Linus Pauling and his colleagues discovered that sickle cell anemia is caused by a mutation in the gene that instructs the synthesis of one of the polypeptide chains of hemoglobin, leading to the production of abnormal hemoglobin molecules that cause red blood cells to assume a sickle shape.

Linus Pauling and His Colleagues Discovered That a Mutant Gene