All epithelial cells in the inner lining of the large intestine that are heterozygous for an APC mutation ____.

Question

Quizplus · Accepted Answer

Heterozygous APC mutations lead to the loss of one functioning copy of the APC gene, which is involved in regulating the cell cycle. While the remaining copy of the gene can still control cell division, it is not as effective as having two functioning copies. This can lead to the formation of clusters of polyps, which can further accumulate additional mutations over time and eventually develop into colon cancer. Therefore, epithelial cells that are heterozygous for an APC mutation can partially escape control of the cell cycle and lead to the formation of clusters of polyps.

All Epithelial Cells in the Inner Lining of the Large