Why is the most damage to the brains of Huntington disease patients observed in the striatum?
A) The Rhes protein, needed for mutant huntingtin to become toxic, is only produced in the striatum.
B) The huntingtin gene is only expressed in the striatum.
C) The mutant huntingtin protein becomes toxic when bound to the Rhes protein, which is abundant in the striatum.
D) Only the cells of the striatum contain the huntingtin mutation.
E) The CAG expansions are corrected in regions of the brain other than the striatum.

Question

Quizplus · Accepted Answer

The mutant huntingtin protein becomes toxic when it binds to the Rhes protein, which is abundant in the striatum. This interaction is a key factor in the pathology of Huntington's disease, leading to the most significant damage in the striatum.

Why Is the Most Damage to the Brains of Huntington