With long term use of antidepressants, there is increased production of brain-derived neurotrophin factor in the:

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The hippocampus is an important region for learning and memory, and it is known to be affected by antidepressant treatment. Long-term use of antidepressants has been shown to increase the production of brain-derived neurotrophin factor (BDNF) in the hippocampus, which is thought to contribute to the antidepressant effects of these drugs. BDNF is a protein that promotes the growth and survival of neurons in the brain, and it is important for learning and memory processes.

With Long Term Use of Antidepressants, There Is Increased Production