Virus particles can be observed by standard transmission microscopy (TEM), but details of capsid structure require visualization by:

Question

Quizplus · Accepted Answer

Cryo-electron microscopy is the technique of choice for visualizing capsid structures of viruses at high resolution. It involves flash-freezing the virus particles in a thin layer of ice and imaging them using an electron microscope. This technique allows for the observation of the detailed structure of the virus capsid. TEM can also be used to observe virus particles, but it provides limited information about the structure and morphology of the capsid. Phase contrast, negative staining, and bright field microscopy are not suitable for visualizing virus capsids. Scanning electron microscopy can provide high-resolution images of the surface of virus particles, but it is not the best choice for studying internal structures like the capsid.

Virus Particles Can Be Observed by Standard Transmission Microscopy (TEM)