GlnB allows cells to balance glutamine synthetase __________ with its rate of __________.

Question

Quizplus · Accepted Answer

GlnB is an intracellular receptor for 2-oxoglutarate levels, which directly affects glutamine synthetase (GS) activity. When 2-oxoglutarate levels are high, GlnB binds to GS to activate it, and when 2-oxoglutarate levels are low, GlnB releases GS to deactivate it. Therefore, GlnB allows cells to balance the rate of GS activity with the available substrate for GS, which is ammonia and glutamate. This balances the activity of GS with the rate of ammonia assimilation into amino acids.

GlnB Allows Cells to Balance Glutamine Synthetase __________ with Its