During the course of an intestinal infection with Salmonella enteritidis, the B cells undergo class switching; what switching is most likely to occur and what causes the switch?

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During an intestinal infection with Salmonella enteritidis, the most likely switching to occur is from IgM to IgA. This is because IgA is the most predominant antibody found in the mucosal surfaces, including the gastrointestinal tract. The switch is primarily caused by the action of T-cell cytokines, particularly transforming growth factor beta (TGF-β) and interleukin-5 (IL-5), which stimulate the B cells to undergo class switching to IgA.

During the Course of an Intestinal Infection with Salmonella Enteritidis