The Human B-Globin Gene Has Two Alleles,H^S and H^A,individuals That

The human b-globin gene has two alleles,H^S and H^A,individuals that are homozygous for H^S have sickle-cell anemia and a lower fitness.Individuals that are heterozygotes (H^SH^A) do not show sickle-cell symptoms and have a resistance to malaria.Individuals that are homozygous for H^A have the highest fitness but are susceptible to malaria.If a vaccine for malaria was created that was 100% effective,affordable,and widely available,how would the frequency of the H^S allele be most likely to change?

A) The H^S allele would increase in regions where malaria is prevalent and decrease in regions where malaria is absent or rare.
B) The H^S allele would decrease in regions where malaria is prevalent and increase in regions where malaria is absent or rare.
C) Due to balancing selection,the frequency of the H^S allele would remain stable in all regions.
D) The H^S allele would increase in regions where malaria is prevalent and remain stable in regions where malaria is absent or rare.
E) The H^S allele would decrease in regions where malaria is prevalent and remain stable in regions where malaria is absent or rarE.