Adenoviruses are a frequent cause of acute upper respiratory tract infections in humans.Adenoviruses have a genome composed of double-stranded DNA,they are non-enveloped and their capsid contains a "fiber" protein that is analogous in function to the spike glycoproteins of HIV.Latency of the adenovirus can occur in lymphoid tissues.Based on this information,which of the following would be the best type of drug to develop to combat adenoviruses in humans?

Question

Quizplus · Accepted Answer

Adenoviruses have a fiber protein on their capsid that binds to receptors on human cells to facilitate entry, so a drug that can bind to these receptors and prevent virus entry would be effective. Inhibiting reverse transcriptase is not useful against adenoviruses, as they are not retroviruses and do not use reverse transcriptase in their replication. Switching off latency is also not a practical option, as latency is a natural part of the virus lifecycle and cannot be completely eliminated. Combination therapies may have some benefits, but a drug that specifically targets the viral entry mechanism is the best option to combat adenoviruses.

Adenoviruses Are a Frequent Cause of Acute Upper Respiratory Tract