Histone Deacetylase Inhibitors Are a Class of Drugs Used as Mood

Histone deacetylase inhibitors are a class of drugs used as mood stabilizers and anti-epileptics that are also being researched for their efficacy as anti-cancer agents.Histone deacetylase inhibitors block the action of histone deacetylases,which remove acetyl groups from lysine residues in histone tails.How will blocking histone deacetylases affect gene expression in the cell?

A) Chromatin will become more tightly compact,and gene expression will be reduced
B) Chromatin will become more tightly compact,and gene expression will be increased
C) Chromatin will become more open,and gene expression will be reduced
D) Chromatin will become more open,and gene expression will be increased
E) Chromatin will become more methylated,and gene expression will be decreased