The reaction: pyruvate + CoA + NAD⁺ $\rarr$ acetyl CoA + CO₂ + NADH,is catalyzed by pyruvate dehydrogenase.If an inhibitor of this enzyme was added to cells levels of which compound would increase in the cytoplasm?

Question

Quizplus · Accepted Answer

If the enzyme pyruvate dehydrogenase is inhibited, then the reaction described in the question will not occur, and pyruvate will not be converted to acetyl-CoA. Therefore, the concentration of pyruvate in the cytoplasm will increase.

The Reaction: Pyruvate + CoA + NAD+ →\rarr→ Acetyl CoA + CO2 + NADH,is Catalyzed by Pyruvate Dehydrogenase

The Reaction: Pyruvate + CoA + NAD⁺ $\rarr$ Acetyl CoA + CO₂ + NADH,is Catalyzed by Pyruvate Dehydrogenase