The biggest drain on Spain's financial resources during the sixteenth century was the cost of

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Supporting the wars of the Habsburgs, particularly in the Netherlands and Italy, was the biggest drain on Spain's financial resources during the sixteenth century. The cost of maintaining a large military and funding military campaigns put a significant strain on the Spanish economy, contributing to its eventual decline in the following centuries. While the other options also imposed financial burdens on Spain, they were not as significant as the cost of waging wars.

The Biggest Drain on Spain's Financial Resources During the Sixteenth