Transcriptionally active genes show lower levels of DNA methylation compared with transcriptionally inactive genes.

Question

Quizplus · Accepted Answer

This statement is true. DNA methylation is a common form of epigenetic modification that involves the addition of a methyl group to the 5-carbon position of the cytosine ring. When DNA is methylated, it usually results in gene silencing or repression, which means that transcription factors cannot access the DNA and initiate gene expression. Therefore, transcriptionally active genes tend to have lower levels of DNA methylation compared with transcriptionally inactive genes. This is because active genes are not silenced by DNA methylation, and their expression is regulated by other mechanisms.

Transcriptionally Active Genes Show Lower Levels of DNA Methylation Compared